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Pillar Guide · Serum Formulation

Niacinamide serum, explained

By Yanse CosmeticsUpdated June 20268 min read

Niacinamide is the backbone of modern oil-control skincare — the most-searched serum active there is, and the partner ingredient in almost every acne-focused formula. This guide covers what it does, the niacinamide + zinc formula brands win with, the right strengths, and how to brief a manufacturer.

Yanse cleanroom — niacinamide serum compoundingInside our factory
Our 100,000-class cleanroom. Niacinamide serums compounded and filled in the same controlled environment as our oil-control range.

Why niacinamide is the backbone active

Niacinamide (vitamin B3) is popular for one reason: it does several useful things at once, gently, and plays well with almost everything. For oily and acne-prone skin it's close to a default — which is why it carries the highest search demand of any serum active and anchors so many ranges, on its own or paired with another hero.

What niacinamide does

  • Balances oil — helps regulate the look of excess sebum and shine.
  • Refines pores — visibly minimises the appearance of enlarged pores over time.
  • Evens tone — supports a brighter, more uniform complexion and fades the look of marks.
  • Supports the barrier — helps skin feel stronger and less reactive, so it suits sensitive skin too.

The formula brands win with

The benchmark structure is niacinamide (5–10%) + zinc in a lightweight base — the classic oil-control serum. From there, partners are tuned to the audience:

LayerWhat to specifyWhy
Hero activeNiacinamide 5–10%Oil, pores, tone, barrier — the core promise
Oil partnerZinc (e.g. zinc PCA)Oil control + clearer look — the classic pairing
Comfort partnerHyaluronic acid / panthenolHydration and tolerance
Tone / acne add-onAzelaic acid, vitamin C derivativeMarks and tone for a fuller acne range
Base & feelLightweight, fast-absorbing, non-greasyThe texture oily-skin users review most
Formulation note

More niacinamide is not better. 5–10% covers the benefit; pushing far higher raises the chance of irritation without added payoff. Stability and a clean, low-odour base matter as much as the percentage.

Strength tiers to offer

  • Gentle (≈5%) — sensitive skin and first-timers.
  • Standard (10% + zinc) — the volume tier; the broadest oily/acne audience.
  • Combination (10% + azelaic or vitamin C) — a multi-active hero for a flagship serum.

Positioning angles (and where they rank)

  • Oily & acne-prone → a niacinamide serum for oily skin with zinc for oil control.
  • Sensitive skin → a gentle 5% niacinamide serum, fragrance-free.
  • Marks & tone → pair niacinamide with azelaic acid for a tone-and-clarity story.

Niacinamide and azelaic are the two pillars of an oily/acne serum range — see the azelaic acid serum guide for the companion active.

Yanse production lineInside our factory
20 years on oily & acne skin. The same specialism behind our oil-control range, extended into serums.

Making it as an OEM / ODM

A specialist manufacturer can formulate niacinamide serums at any tier, add zinc or other partners, set the base and texture, run stability and trial batches, and scale into your packaging. Tell us your audience and we'll propose a formula and send samples.

Develop your niacinamide serum

Tell us your audience and strength — we'll propose a niacinamide + zinc formula tuned for oily, acne-prone or sensitive skin, and return samples with a 24-hour quote.

Request free samples →

Free sample set · 24-hour quote · MOQ from 3,000 · 妆字号 + ISO 22716

Educational content for brand and product teams. Ingredient and claim information is general and varies by market regulation; finished-product claims and permitted concentrations should be confirmed against the rules of your target market. Yanse Cosmetics is a contract manufacturer (OEM/ODM) and does not sell finished consumer goods under its own brand.

Frequently asked questions

What does a niacinamide serum do?

Niacinamide (vitamin B3) helps balance oil, visibly refine pores, even tone and support the skin barrier. It is gentle and broadly compatible, which is why it is one of the most popular serum actives for oily and acne-prone skin.

What percentage of niacinamide is best in a serum?

Most serums use around 5–10%. 10% is the popular benchmark (often with 1–2% zinc for oil), while 5% suits sensitive skin. Higher is not necessarily better and can increase the chance of irritation.

Why is niacinamide paired with zinc?

Zinc (often zinc PCA) supports oil control and a clearer-looking complexion, so niacinamide + zinc is the classic combination for oily and blemish-prone skin — the structure behind many best-selling oil-control serums.

Can you use niacinamide with azelaic acid?

Yes — niacinamide and azelaic acid are complementary and frequently combined. Niacinamide handles oil, pores and barrier while azelaic works on marks and redness, making them a strong pairing for an oily/acne range.

Can an OEM manufacturer make a custom niacinamide serum?

Yes. A specialist OEM/ODM manufacturer can formulate niacinamide serums at different strengths, add zinc or other partners, choose the base and texture, run stability and trial batches, and scale with your packaging. MOQ from 3,000.